A monumental milestone in India’s medical history was reached after the first patient was completely rid of cancer using an indigenous CAR-T cell therapy, NexCAR19. This pioneering development promises more affordable access to advanced cell-based cancer treatment for patients in India.
Understanding CAR-T Cell Therapy
CAR-T cell therapy is a form of immunotherapy where T cells(an essential type of white blood cell in the immune system, also known as, T Lymphocytes), essential players in immune response, are extracted from a patient’s blood sample and genetically modified in the lab to produce specific chimeric antigen receptors on their surface.
These engineered receptors equip the T cells to recognize and mount attacks against cancer cells when reintroduced into the patient’s body via transfusion, while sparing healthy cells. Continuous proliferation of these transfused CAR T cells helps sustain their anti-cancer action.
CDSCO Approval of India’s First CAR-T Therapy
In October 2023, NexCAR19 became the first CAR-T therapy approved for commercial use in India by the Central Drugs Standard Control Organisation (CDSCO), the national regulatory body. Developed by ImmunoACT, an IIT Bombay-based startup, it is indicated for certain relapsed or chemotherapy-resistant blood cancers.
First CAR-T Therapy Cancer Patient in Remission
67-year old Dr. V.K Gupta from Delhi, suffering from chronic lymphatic leukemia, became the first patient to be administered NexCAR19 at Manipal Hospital Delhi after regulatory nod last year.
Now, months after Infusion of this personalized cell therapy, Dr. Gupta has been declared free of cancer cells and is in remission.
Indigenous Development Makes Treatment Affordable
Unlike established global CAR-T treatments which cost upwards of Rs 4 crores, NexCAR19 therapy for Dr. Gupta amounted to Rs 42 lakhs only. Its indigenous development gives India a more affordable alternative to benefit many more eligible cancer patients through this curative emerging technology.
This achievement augurs well for India’s healthcare ecosystem and highlights the budding potential for use of gene and cell therapies against complex diseases. Next steps involve expanding capacity along with continuous enhancements.
The breakthrough also serves to attract interest from global investors looking to enter India’s expanding precision medicine industry.
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